For Brutality builds, it is possible to back it up with Vampirism and the Recovery mutation to compensate for any mistakes made while the skill is active.
Beware that some damage sources have a specified limit which will ignore the skill's negative attribute, such as being hit by traps while Masochist is active.
As ironic as it may seem, Corrupted Power works well with Cursed Sword, further capitalizing on the already high damage while forcing the player to dodge all enemy attacks to avoid death, hence technically eliminating its downside.
Notes
Corrupted Power is best used for burst damage. As a trade-off, the player needs to avoid attacks to the best of their abilities in order to take maximum advantage of the skill.
While Corrupted Power does not work with traditional damage over time effects, it does apply to the mutation Barbed Tips.
Corrupted Power works differently from the damage boosting mutations in that instead of increasing a damage value by a percentage, it creates an additional damage instance which deals half the damage of the original.
Can increase the damage dealt by skills too, provided that they deal ranged or melee damage, such as Scarecrow's Sickles and Pollo Power.
The direct damage applied by these items is not affected by damage boosting mutations either. However, status effects they inflict by design (e.g. Flamethrower Turret, Cleaver) or through affixes can be affected by damage boosting mutations (but not by Corrupted Power).
Corrupted Power does not increase the bonus damage dealt by Wolf Trap itself, but it still affects the ranged and melee damage instances which are buffed through Wolf Trap's affix transfer mechanic. Furthermore, Wolf Trap reapplies its affix transfer mechanic on the new damage instances created by Corrupted Power.