For Brutality builds, it is possible to back it up with Vampirism and the Recovery mutation to compensate for any mistakes made while the skill is active.
Beware that some damage sources have a specified limit which will ignore the skill's negative attribute, such as being hit by traps while Masochist is active.
As ironic as it may seem, Corrupted Power works well with Cursed Sword, further capitalizing on the already high damage while forcing the player to dodge all enemy attacks to avoid death, hence technically eliminating its downside.
Corrupted Power is best used for burst damage. As a trade-off, the player needs to avoid attacks to the best of their abilities in order to take maximum advantage of the skill.