Mutations

Mutations are passive upgrades that modify and increase the abilities of the player in various ways. They are obtained between levels from a Guillain. Most are not initially available, so in order to unlock them, one must bring their blueprints to the Collector, then spend the required cells.

Mechanics

The player can only have a certain number of mutations at once. Each area cleared in a run allows one more mutation, up to a total of 3 (unless in custom mode, where many more can be picked). However, the player can spend gold between levels to remove all current mutations, allowing a new choice of mutations to replace the old set. The price to do this starts at 1,000 and doubles with each reset, until the cost reaches 8,000 gold, at which point it will stop increasing.

Most mutations are associated with and scale their benefits with a specific stat. That is, mutations' base damage and/or healing magnitudes are multiplied by 1.15^n-1, where n is the current level of the appropriate stat, rounded to produce the final amount.

For example, if a Brutality mutation provides an extra 90 base DPS and the player's Brutality is 2, the final extra DPS is 90 × 1.15^2-1 = 90 × 1.15 = 103.5 ≈ 104). Note that damage and DPS bonuses from mutations are not affected by gear-specific damage bonuses or Affixes.

Colorless mutations have fixed benefits unaffected by Stats, except for Instinct of the Master of Arms and Frostbite which scale on the highest stat.

List of mutations

There are 53 mutations in the game: 12 for Brutality, 12 for Tactics, 12 for Survival and 17 that are Colorless.

List of Brutality mutations

Icon	Name	Description	Location	Cell cost
	Killer Instinct	Reduces the cooldown of your skills by [0.4 base, 3 max] seconds for each enemy killed in hand to hand combat.	Always available	N/A
	Combo	Each consecutive hit that connects continues your combo, increasing your damage dealt. The combo expires after 2.5 sec or if you are dealt damage.	Always available	N/A
	Vengeance	+[60% base] damage dealt for 8 seconds and -30% damage taken for 3 seconds after taking damage.	Always available	N/A
	Melee	Melee attacks slow down enemies for [0.4 base, 1.6 max] seconds.	The Concierge (5th kill)	50
	Open Wounds	Your close combat attacks inflict bleeding ([18 base] DPS for 1.5 seconds)	Lacerators (0.4%)	50
	Tainted Flask	Using a health flask adds +[20% base] damage to your attacks for 20 sec. If you have at least one empty flask charge, it will refill a charge after killing [12 base, 4 min] Elite enemies. Also causes 1 more Elite to spawn in each biome.	The Time Keeper (6th kill)	50
	Adrenaline	Melee attacks restore a small amount of HP depending on attack damage for 5 sec after dodging an attack at the last moment.	Rampagers (3+ BSC; 1.7%)	100
	Frenzy	Melee attacks restore a small amount of HP depending on attack damage as long as you have an active speed buff.	Timed door in the Passage before Toxic Sewers	50
	Scheme	Your next melee attack after using a skill inflicts +[200 base] damage.	Sweepers (10%)	50
	Initiative	Your first melee strike against an enemy inflicts +[100 base] damage.	Royal Guards (10%)	50
	Predator	Killing an enemy with a melee strike makes you invisible for [1 base, 2.8 max] seconds.	Automatons (10%)	50
	Porcupack	Rolling through enemies attacks them with the melee weapon in backpack for [75% base] of the usual damages.	Rancid Rats (0.4%)	80

List of Tactics mutations

Icon	Name	Description	Location	Cell cost
	Support	+[35% base] damage if you're close to a deployed skill.	Always available	N/A
	Parting Gift	Causes a bomb ([75 base] damage) to appear when you kill an enemy with a non-melee attack.	Secret area in Graveyard	100
	Tranquility	+[25% base] damage if there are no enemies near you.	Always available	N/A
	Ripper	Hand to hand attacks cause 6 arrows stuck in the attacked enemy to fall out, each one dealing [118 base] damage.	Secret area in Promenade of the Condemned	100
	Ranger's Gear	Your next ranged attack after using a skill inflicts [180 base] damage.	Dancers (10%)	50
	Barbed Tips	Inflicts [40 base] dps per arrow stuck to enemies.	Toxic Miasmas (10%)	80
	Point Blank	Close-ranged ranged attacks inflicts [30 base]% bonus damage.	Corpulent Zombies (10%)	80
	Networking	Enemies hit with a ranged attack are marked for 8 sec. Marked targets share [35% base, 75% max] of the damage they receive.	Swarm Zombies (10%)	50
	Crow's Foot	Rolling leaves 3 crow's feet behind you (with a maximum of 9), inflicting [50 base] damage and slowing the enemies for 1.5 seconds.	Inside a chest in a Challenge Rift	50
	Tactical Retreat	Dodging an attack at the last moment slows down nearby enemies for [1 base, 3 max] seconds.	Slammers (10%)	100
	Hunter's Instinct	Decreases skill cooldowns by [0.3 base, 2.5 max] seconds for each enemy killed without using melee attacks.	Always available	N/A
	Acrobatipack	Attacking with a ranged weapon, after rolling with a ranged weapon in your backpack fires a projectile of said weapon, dealing [25% base] of the usual damages.	Demolishers (10%)	120

List of Survival mutations

Icon	Name	Description	Location	Cell cost
	Soldier's Resistance	Increases your health by [5% base. 40% max].	Guardian Knights (1.7%)	100
	Berserker	Killing an enemy with a melee attack reduces the damage you take by [5% base, 20% max] for 8 sec. Can stack up to 90%. Also makes you immune to stuns.	Failed Experiments (4+ BSC; 0.4%)	100
	Blind Faith	Reduces the cooldown on your skills by [2.8 base, 6 max] seconds with each successful parry.	Always available	N/A
	Counterattack	The attack following a successful parry inflicts +[210 base] damage.	Always available	N/A
	What Doesn't Kill Me	Recover [2% base, 6% max] HP after parrying a melee attack.	Disgusting Worms (100%)	50
	Necromancy	Recover [0.3% base, 3% max] of your max HP after killing an enemy. This effect scales with the victim's max health and is reduced as you get closer to full health.	Always available	N/A
	Extended Healing	Your health flask heals 100%, its effect is spread over 12 seconds and you deal +[25% base] damage during this time.	Secret area in Ossuary	100
	Gastronomy	The effect of food increases by +65%. If you recycle food you deal +[10% base] damage for 300 seconds.	Conjunctivius (4th kill)	50
	Spite	Successful parries and reflected shots inflict [140 base] damage.	Secret area in Passage to Toxic Sewers	100
	Heart of Ice	Attacking a frozen, stunned or rooted enemy at close range reduces skill cooldowns by [0.6 base, 2 max] seconds. Works with both melee and ranged weapons.	Pirate Captains (10%)	50
	Kill Rhythm	Alternate weapons to increase your attack speed by [15% base].	Oven Knights (2+ BSC; 0.4%)	150
	Armadillopack	Rolling also parries attack and projectiles with the shield in your backpack, for [50% base] of the usual damages.	Thornies (1.7%)	100

List of Colorless mutations

Icon	Name	Description	Location	Cell cost
	Frostbite	Enemies suffer [30 base] DPS while they are slowed down.	Buzzcutters (10%)	100
	Ygdar Orus Li Ox	Saves you ONE TIME if you die prematurely while not cursed. Cannot be picked up after first mutation selection. Cannot be dropped once picked up, even if used.	Always available	N/A
	Recovery	Time available to recover your health after a hit is multiplied by 3.	Conjunctivius (5th kill)	50
	Emergency Triage	Health potions only restore 35% HP but their use speed is increased by 275% and it completely protects you for 2 sec.	The Time Keeper (7th kill)	100
	Velocity	Running speed duration bonus (for kill combo) multiplied by 3.	The Time Keeper (5th kill)	50
	Dead Inside	Increases your maximum health by 100%, but deactivates all sources of healing except for recovery.	Lancers (4+ BSC; 1.7%)	100
	Alienation	Reducing a curse restores 5% HP but increases the number of enemies required to lift the curse by 50%.	The Concierge (7th kill)	50
	Acceptance	Amount of kills required to remove a curse is reduced by 50%, but consuming food curses you.	Secret area in High Peak Castle	200
	Masochist	Trap damage is capped at 10% of your max HP. When hit by a trap your movement speed increases by 20% for 20 sec.	Secret area in Slumbering Sanctuary	100
	Disengagement	Once per biome, if your HP falls below 15%, a force field protects you for 5 sec.	Secret area in Prisoners' Quarters	200
	No Mercy	Execute mobs under 15% health. Effect halved on bosses.	Slashers (1.7%)	100
	Instinct of the Master of Arms	Reduces the cooldown on your skills by [0.08 base, 1 max] sec with each critical hit.	Always available	N/A
	Ammo	Ammo for your weapons is now 2 times what it was.	The Concierge (6th kill)	50
	Gold Plating	Lose gold instead of health when hit. The gold lost is proportional to the health loss prevented.	Mimics (10%)	50
	Get Rich Quick	Accumulate bonus gold for every enemy killed while you have an active speed boost and cash it in when it ends.	Mimics (10%)	50
	Midas' Blood	Gain 1.6 gold per health points you lose.	Gold Gorgers (1.7%)	50
	Wish	Turns the next item picked legendary. Cannot be removed once activated. Cannot be removed. Let's hope it was worth it.	Reward for beating the 3rd Stage in Boss Rush	200
	Cursed Flask	Your health flask has infinite charges but also curses you 20 times each time you use it.	Curser (10%)	150
	Damned Vigor	Upon being dealt fatal damage, you stay alive for 2 seconds. If you kill any enemy while under this effect, you get back to 1 health point. Otherwise, when the effect dissapears or you get hit while under it, you instantly die without any sort of protection applicable.	Sore Loser (10%)	200
	Demonic Strength	You deal 30% more damage as as you are cursed. This bonus is increased by 2% per curse stack you have.	Doom Bringer (10%)	100

Removed mutations

Icon	Name	Description	Location	Cell cost	Removed in
	Sadism	+[75 base] DPS if a nearby enemy is taking poison, bleed or burn damage.	Was dropped by Impaler (100%)	50	v1.1
	Fireworks Technician	-[30% base, 80% max] cool down delay when using your Grenades.	Always available	N/A	v1.1
	Efficiency	-[30% base, 80% max] cool down delay when using your skills.	Always available	N/A	v1.1

History

0.5: Introduced with Combo, Vengeance, Melee, Tainted Flask, Efficiency, Support, Parting Gift, Tranquility, Ripper, Soldier's Resistance, Counterattack, What Doesn't Kill Me, Necromancy, Extended Healing, Gastronomy, Ammo, Ygdar Orus Li Ox, Recovery, Emergency Triage, Velocity and Alienation 0.6: Introduced Dead Inside and Fireworks Technician. 0.7: Introduced Disengagement, Acceptance, Masochist, Fireworks Technician and Spite. 1.1: Introduced Killer Instinct, Open Wounds, Hunter's Instinct, Blind Faith and Instinct of the Master of Arms. Removed Sadism, Fireworks Technician and Efficiency. 1.2: Introduced Berserker. 1.3: Introduced Adrenaline and Frenzy. 1.4: Introduced Scheme, Initiative and Predator. 1.5: Introduced Networking, Crow's Foot and Tactical Retreat. 1.6: Introduced Frostbite and Heart of Ice. 1.9: Skills no longer activate cooldown reduction mutations. 2.1: Introduced Porcupack, Ranger's Gear, Acrobatipack, Kill Rhythm and Armadillopack. 2.3: Introduced Point Blank, Barbed Tips and No Mercy. 2.8: Introduced Midas' Blood, Gold Plating and Get Rich Quick.