Works very well with the mutations Vengeance, Adrenaline and Recovery, letting yourself get hit on purpose to proc critical and DPS bonus to quickly heal a lot of health.
Blocking with any shield can enable critical hits more safely and easily by allowing you to take significantly lower damage from enemy hits.
Face Flask can enable critical hits on use without having to take damage from enemy hits. Using it with Instinct of the Master of Arms can allow to deal critical DPS permanently.
Critical hit condition is almost opposite to Flawless. Mixing these weapons can provide a pretty decent amount of critical damage depending on whether damage has been recently taken or not.